Jayasurya has acted in several films in Malayalam and Tamil. Jayasurya became popular among family audiences as an anchor in musical programs on Malayalam television. He also played minor roles in films. Notable among these was the comedy artist in Aparanmar Nagarathil. He made his debut in 2001 in the Malayalam film Dosth. The years 2002 and 2003 were the age of newcomers; the superstars seemed to be fading. Though he acted in flops like Pranaya Mani Thooval and Kattu Chembakam, he was considered a promising talent for the coming years. In 2003, he acted in Swapnakkoodu with Prithviraj and Kunchacko Boban. Jayasurya’s next appearances were in the back-to-back mega hits Pulival Kalyanam and Chathikatha Chanthu, directed by Shafi and Rafi-Mekartin respectively. It was very rare in the Malayalam film industry to have back-to-back hits, and it seemed Jayasurya was set to be the next big star.

He was cast as a villain opposite Sreenivasan in Lal Jose’s Arabikkatha, which was a hit. This followed villain roles in Hareendran Oru Nishkalankan and Kangaroo. He played a variety of roles in 2007–2008: the romantic lover with a comic touch in Chocolate, the serious police officer in Positive, the humorous drama scriptwriter in Shakespeare M.A. Malayalam, the small-time thief in LollyPop, the supporting role in Love in Singapore, and the young politician in De Ingottu Nokkiye. In 2011, he appeared in 20 get-ups in T. V. Chandran’s comedy-fantasy film Sankaranum Mohananum.

Jayasurya was born in 1978 to Mani and Thankam in Thrippunithara. In 2004, he married his longtime girlfriend Saritha; they have one son, Adwaith.