Murali Sharma was born in Guntur, to a Telugu family. He is married to actress Ashwini Kalsekar and lives in Mumbai. While doing films, he has also appeared in soap opera’s such as Guns and Roses, Siddanth and Arun Frank’s Zindagi Teri Meri Kahani on STAR One. In March 2013 he was seen in a few episodes of a crime show called Hum Ne Li Hai- Shapath, which airs on Life OK every Saturday and Sunday at 9pm. He played the character of tour guide Rangeela Ratan Sisodia.