Ousephachan was born to Mechery Louis and Mathiri Paliakkara on 13 September 1954 in Ollur, Thrissur, Kerala, India. He completed his formal education from Saint Thomas College, Thrissur. He was interested in music and by the time he finished his formal education, he had become an expert violinist. He started his music career as violinist in some music troupes. Later he got the chance to be the violinist in concerts of renowned playback singer Madhuri. He later became the violinist under music director Paravoor Devarajan master. Then he moved to Madras, Tamil Nadu where most of the recording works of Malayalam films were done. His first work in the film industry was the film Eenam, for which he set the background score. He composed the soundtrack for the film Aaravam (1979), however Kathodu Kathoram (1985), directed by Bharathan is considered as his debut. Ouseppachan's work was noted for the film and three songs from the film became super hits. These songs were noted also for the immense use of violin. This may be attributed to the facts that Ousephachan himself is a violinist and that the protagonist of the film played by Mammootty is also a violinist. Ousephachan then went on to compose music for over 60 films. Music Maestro A. R. Rahman associated with him for most of his films in late 80s. He also composed songs for the Hindi film Freaky Chakra, directed by V.K. Prakash and background scores for various other Hindi films. Aside from music direction, he has taken up a spot as a judge for Asianet's Idea Star Singer 2008.