Pooja Gandhi was born in Ganjimutt, Vandela, on October 7 in a traditional Punjabi family. Her father Pawan Gandhi is a businessman and her mother Jyothi Gandhi is a housewife. She studied at Sophia Convent and Dewan Public School in Meerut. She has two younger sisters, Radhika Gandhi, who is also working in Kannada films, and Suhani Gandhi, a tennis player. Pooja Gandhi was set to marry Anand Gowda a realtor, who is a divorcee. However the two decided to part ways due to differences.
Pooja Gandhi started her career by acting in soaps, starting with Zameen Se Asman directed by Aruna Irani. She made her debut in the Bengali film Tomake Salam, released in 2003. She moved to the South Indian film industry with the Tamil film Kokki, which did not show promising results at the box office. She entered the Kannada film industry with Mungaru Male, a film that became a big hit in Karnataka, and she popularly came to be known as Mungaru Male Hudugi. Pooja Gandhi acted in the Kannada movie Krishna, opposite “Comedy Time” Ganesh, her co-actor in Mungaru Male. She has since acted in several Kannada films including Kodagana Koli Nungitha, Manmahta, Milana, Budhivanta, Huchchi, Taj Mahal and Honey Honey. Sanjana Gandhi has signed up to make her Tulu language film debut in Beere Devupoonje, playing the role of Raja Nartaki. The film, produced and directed by R. Dhanraj, will be based on a Tulu warrior named Devapoonja who lived 400 years ago.
Pooja Gandhi has joined Janata Dal (S) on 18 Jan 2012. The party had initially appointed her as the working president of its youth wing but later began to sideline her, following criticism by opposition members. Former Member from BJP of Parliament Ayanur Manjunath had attacked Pooja Gandhi saying that she is the Dandupalya queen. Pooja had acted in the film Dandupalya which was based on the dreaded gangsters of Dandupalya. While Manjunath criticized Pooja publicly, Speaking to reporters, Gandhi claimed to be hurt by the treatment. Former Chief Minister H D Kumaraswamy who is also the state president of the party said that if Pooja Gandhi was not comfortable in JDS, she can join other party. Six months after she joined politics through Janatha Dal Secular JDS, actress Pooja Gandhi has bid adieu to the JD(S) party. Pooja has joined the new party as nobody came to her rescue when she was being criticized in JDS.
Pooja Gandhi was to join the KJP at the December 9th Haveri convention, but decided to formally become inducted into the party on December 7th 2012. Pooja was inducted into the KJP by party state executive member Ishwaraya and State Secretary Madan Patel. She has now joined former Chief Minister B S Yeddyurappa’s new party Karnataka Janatha Party (KJP) & she showed up offically with KJP on December 9 at Haveri convention.