Ramya Krishnan was born in a Tamil Iyer Brahmin family, in Chennai. She had initial training in Bharathanatyam and Kuchipudi dance forms and had given many stage performances. She is the niece of veteran Tamil comedian Cho Ramaswamy. She married Telugu film director Krishna Vamsi on 12 June 2003 and has since then settled in Hyderabad. She gave birth to a baby boy, named Ritwik, in February 2005.
Ramya Krishnan started her acting career at the age of 13 and has an acting career spanning over 28 years. She first played the lead role in Vellai Manasu, a Tamil film opposite Y. Gee. Mahendra. She was studying in 9th standard when she acted in that film. Ramya’s first Telugu film was Bhalae Mithrulu. She achieved fame through Kasinadhuni Viswanath’s Suthradharulu, released in 1987. Her Tamil film Padayappa (1999), was also released in Japan, Singapore, London and Paris. She won a wide recognition for her role as Neelambari, the villain. After Padayappa she has acted in Panchathanthiram, Paattali, Paarai, Vaanjinathan, Budget Pathmanaban and Asathal. She appeared in item numbers for the movies Rhythm and Kuthu and in Hindi films such as Khalnayak and Dayavan.
She is most noted for roles of the Goddess in Tamil and Telugu films, notably Ammoru (Amman in Tamil), Rajakaliamman and Annai Kaligambal. One of her earliest movie roles was in the Kannada film Krishna Rukmini which has been followed with Gadibidi Ganda, Mangalyam Thanthunanaena and Raktha Kanneeru. She has performed in some stage shows in New York, Dallas, San Jose, and Cincinnati. She started a company in the name of her son Ritwik. She is now hosting an entertainment show Zara Masti Zara Dhoom. She was a judge in a dancing show on Star Vijay: Jodi Number One, season 1, followed by season 5.