Santhosh Pandit was born in Peruvannamuzhi village and was brought up in Kozhikode city. He went to school at Chelannur AKKR High School and the Government Arts College. After his parents died, he inherited three houses, one of which he sold to raise funds for his first film. He is divorced and has a son.

Santhosh Pandit is known for his directorial debut film Krishnanum Radhayum in which he appeared in the lead role and handled almost all the major departments of the film. The songs and trailers of the film went viral in You Tube after it was released there before the release of the film.
As per Google Trends, he was the 10th most popular search from India on November 10, 2011. However, his web site claims that he was at the 6th on Google Trends, probably due to fluctuations in ranking during the course of the day. Interestingly, India stood only fifth among the countries that had searched for him. NRI Malayalees gave more attention to him, as Qatar stood top of the list, followed by Bahrain, United Arab Emirates and Kuwait.

Santhosh Pandit’s first movie Krishnanum Radhayum which got released on 21 October 2011 became an un-expected crowd puller and saw some success in theaters. Some critics attribute the moderate success of the film to the general curiosity after the unprecedented abuses and negative comments posted on the You Tube clips related to the songs in the film. Santhosh is credited as an actor, director, script-writer, editor, music director, lyric writer, editor and playback singer in the film and he stands a chance for entering record books for the maximum credits for a single person in a released film.