Suhasini was born on 15 August 1961 in Chennai to actor Charuhasan, the elder brother of Kamal Hassan. Suhasini has acted in Telugu, Tamil, Kannada and Malayalam films. She started her career as a make-up artist for several leading actors at that time. In Kannada, she acted in several movies like Bandhana and Muttina Haara (1990) directed by Rajendra Singh Babu, Benkiyalli Aralida Hoovu (1983) directed by K. Balchander, and Suprabhatha, directed by Dinesh Babu. In Kannada films, she is a popular artist, especially in Vishnuvardhan movies which were hits at box office. She was introduced to Malayalam cinema through Padmarajan’s Koodevide (1983), which also featured Mammootty. Her role in the AFI Fest-nominated feature Vaanaprastham (1999), which starred Mohanlal, was particularly well received.
Suhasini won the National Film Award for Best Actress in 1986 for her role in the 1985 Tamil film Sindhu Bhairavi, directed by K. Balachander. In 1996, Suhasini stepped into direction with Indira. She also wrote the screenplay for the film. The project was produced by G. V. Films. Suhasini and her husband Mani Ratnam are involved in the running of their production company Madras Talkies, with G. Srinivasan. Majority of Suhasini’s movies are in Telugu. She acted with popular actors such as Krishna and Chiranjeevi. With Chiranjeevi, she appeared in over 20 films which are mostly box-office successes. Her latest appearance in the Telugu movie Leader was well received.