V Harikrishna debuted in Kannada music industry with his catchy tunes and hummable songs through the movie Jothe Jotheyali. He is the son-in-law of famous music director G. K. Venkatesh. He has worked with many famous music directors such as Hamsalekha, V Ravichandran and others as an assistant since 1987. He became an independent music director with the film Jothe Jotheyali in 2006 for the Thoogudeepa Productions banner and became a permanent fixture for all Darshan Thoogudeep's films starting from Snehana Preethina to date. He is also scoring music for Darshan Thoogudeep starrer Porki and Puneet Rajkumar starrer Raaj-The Showman.
His music from all his films have topped the music charts, in movies like Payana, Gaja, Gaalipata, Krishna, Junglee, Ambaari,. His melodious Duet songs or love ballads to Dance Songs to patho filled songs are all hit with the audience.